CD274 antibody

References #6
Category:
Catalogue No.: 
FNab06280
Alias: 
Programmed cell death 1 ligand 1 (PD-L1 antibody, PDCD1 ligand 1 antibody, Programmed death ligand 1 antibody, hPD-L1)|B7 homolog 1 (B7-H1)|CD274|B7H1|PDCD1L1|PDCD1LG1|PDL1 antibody
Gene Name: 
CD274
UniProt ID: 
Q9NZQ7
Size Price
100μg Inquiry
Dispatch Time: About 3 working days
Contact Us
Product Name
CD274 antibody
Catalogue No.
FNab06280
Gene Name
CD274
UniProt ID
Q9NZQ7
Alias
Programmed cell death 1 ligand 1 (PD-L1 antibody, PDCD1 ligand 1 antibody, Programmed death ligand 1 antibody, hPD-L1)|B7 homolog 1 (B7-H1)|CD274|B7H1|PDCD1L1|PDCD1LG1|PDL1 antibody
Isotype
IgG
Form
liquid
Purification
Immunogen affinity purified
Immunogen
CD274 molecule
Recommended dilution
WB: 1:200-1:1000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100
Purity
≥95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background
Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).?


Figures for this product are not available in this catalogue.

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Dispatch Time
About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.

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Cited Publications (6)

Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy IF: 4.4

EJNMMI Radiopharmacy and Chemistry · 2025-02-07

Deoxynivalenol upregulates hypoxia-inducible factor-1α to promote an “immune evasion” process by activating STAT3 signaling IF: 3.9

Food and Chemical Toxicology · 2024-07-12

Tc-Labeled Cyclic Peptide Targeting PD-L1 as a Novel Nuclear Imaging Probe IF: 5.4

Pharmaceutics · 2023-12-01

Synthesis and Evaluation of 177Lu-DOTA-PD-L1-i and 225Ac-HEHA-PD-L1-i as Potential Radiopharmaceuticals for Tumor Microenvironment-Targeted Radiotherapy IF: 5.6

International Journal of Molecular Sciences · 2023-08-11

PD-L1 expression is linked to tumor-infiltrating T cell exhaustion and adverse pathological behavior in pheochromocytoma/paraganglioma IF: 5

Laboratory Investigation · 2023-07-07

ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer IF: 8.593

Experimental Hematology & Oncology · 2023-06-02

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