ADAM17 antibody

References #1
Category:
Catalogue No.: 
FNab00138
Alias: 
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)|Snake venom-like protease|TNF-alpha convertase|TNF-alpha-converting enzyme|ADAM17|CSVP|TACE antibody
Gene Name: 
ADAM17
UniProt ID: 
P78536
Size Price
100μg Inquiry
Dispatch Time: About 3 working days
Contact Us
Product Name
ADAM17 antibody
Catalogue No.
FNab00138
Gene Name
ADAM17
UniProt ID
P78536
Alias
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)|Snake venom-like protease|TNF-alpha convertase|TNF-alpha-converting enzyme|ADAM17|CSVP|TACE antibody
Isotype
IgG
Form
liquid
Purification
Immunogen affinity purified
Immunogen
ADAM metallopeptidase domain 17
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:100 - 1:200
Purity
≥95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease.


Figures for this product are not available in this catalogue.

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Dispatch Time
About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.

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Cited Publications (1)

Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease IF: 5.4

Journal of Ethnopharmacology · 2023-11-10

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