CYP3A4 antibody

References #3
Category:
Catalogue No.: 
FNab02165
Alias: 
Cytochrome P450 3A4|1 antibody, 4-cineole 2-exo-monooxygenase|1 antibody, 8-cineole 2-exo-monooxygenase|Albendazole monooxygenase (sulfoxide-forming)|Albendazole sulfoxidase|CYPIIIA3|CYPIIIA4|Cholesterol 25-hydroxylase|Cytochrome P450 3A3|Cytochrome P450 HLp|Cytochrome P450 NF-25|Cytochrome P450-PCN1|Nifedipine oxidase|Quinine 3-monooxygenase|CYP3A4|CYP3A3 antibody
Gene Name: 
CYP3A4
UniProt ID: 
P08684
Size Price
100μg Inquiry
Dispatch Time: About 3 working days
Contact Us
Product Name
CYP3A4 antibody
Catalogue No.
FNab02165
Gene Name
CYP3A4
UniProt ID
P08684
Alias
Cytochrome P450 3A4|1 antibody, 4-cineole 2-exo-monooxygenase|1 antibody, 8-cineole 2-exo-monooxygenase|Albendazole monooxygenase (sulfoxide-forming)|Albendazole sulfoxidase|CYPIIIA3|CYPIIIA4|Cholesterol 25-hydroxylase|Cytochrome P450 3A3|Cytochrome P450 HLp|Cytochrome P450 NF-25|Cytochrome P450-PCN1|Nifedipine oxidase|Quinine 3-monooxygenase|CYP3A4|CYP3A3 antibody
Isotype
IgG
Form
liquid
Purification
Immunogen affinity purified
Immunogen
cytochrome P450, family 3, subfamily A, polypeptide 4
Recommended dilution
WB: 1:500 - 1:2000; IHC: 1:20 - 1:200; IF: 1:20 - 1:200
Purity
≥95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.


Figures for this product are not available in this catalogue.

Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Dispatch Time
About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.

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Cited Publications (3)

Molecular Mechanisms of the Regulation of Liver Cytochrome P450 by Brain NMDA Receptors and via the Neuroendocrine Pathway—A Significance for New Psychotropic Therapies IF: 5.6

International Journal of Molecular Sciences · 2023-12-08

The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats IF: 4.4

Pharmacological Reports · 2023-10-27

The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice IF: 3.919

Pharmacological Reports · 2022-09-02

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