Products
FGFR1 antibody
Category:
- Catalogue No.:
- FNab03099
- Alias:
- Fibroblast growth factor receptor 1 (FGFR-1)|Basic fibroblast growth factor receptor 1 (BFGFR antibody, bFGF-R-1)|Fms-like tyrosine kinase 2 (FLT-2)|N-sam|Proto-oncogene c-Fgr|FGFR1|BFGFR|CEK|FGFBR|FLG|FLT2|HBGFR antibody
- Gene Name:
- FGFR1
- UniProt ID:
- P11362
- Product Name
- FGFR1 antibody
- Catalogue No.
- FNab03099
- Gene Name
- FGFR1
- UniProt ID
- P11362
- Alias
- Fibroblast growth factor receptor 1 (FGFR-1)|Basic fibroblast growth factor receptor 1 (BFGFR antibody, bFGF-R-1)|Fms-like tyrosine kinase 2 (FLT-2)|N-sam|Proto-oncogene c-Fgr|FGFR1|BFGFR|CEK|FGFBR|FLG|FLT2|HBGFR antibody
- Isotype
- IgG2a
- Clone ID
- 8D2
- Form
- liquid
- Purification
- Protein A+G purification
- Immunogen
- fibroblast growth factor receptor 1
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:50-1:500
- Purity
- ≥95% as determined by SDS-PAGE
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Background
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone(GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Figures for this product are not available in this catalogue.
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Dispatch Time
- About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.
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Product Inquiry
FNab03099 — FGFR1 antibody