Products
NLRP1 antibody
Category:
- Catalogue No.:
- FNab05757
- Alias:
- NACHT antibody, LRR and PYD domains-containing protein 1|Caspase recruitment domain-containing protein 7|Death effector filament-forming ced-4-like apoptosis protein|Nucleotide-binding domain and caspase recruitment domain|NACHT antibody, LRR and PYD domains-containing protein 1 antibody, C-terminus (NLRP1-CT)|NACHT antibody, LRR and PYD domains-containing protein 1 antibody, N-terminus (NLRP1-NT)|NLRP1|CARD7|DEFCAP|KIAA0926|NAC|NALP1 antibody
- Gene Name:
- NLRP1
- UniProt ID:
- Q9C000
- Product Name
- NLRP1 antibody
- Catalogue No.
- FNab05757
- Gene Name
- NLRP1
- UniProt ID
- Q9C000
- Alias
- NACHT antibody, LRR and PYD domains-containing protein 1|Caspase recruitment domain-containing protein 7|Death effector filament-forming ced-4-like apoptosis protein|Nucleotide-binding domain and caspase recruitment domain|NACHT antibody, LRR and PYD domains-containing protein 1 antibody, C-terminus (NLRP1-CT)|NACHT antibody, LRR and PYD domains-containing protein 1 antibody, N-terminus (NLRP1-NT)|NLRP1|CARD7|DEFCAP|KIAA0926|NAC|NALP1 antibody
- Isotype
- IgG
- Form
- liquid
- Purification
- Immunogen affinity purified
- Immunogen
- NLR family, pyrin domain containing 1
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
- Purity
- ≥95% as determined by SDS-PAGE
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Background
- As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death(PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide(MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner(PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin(PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release(PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP(PubMed:17349957). Binds ATP(PubMed:11113115, PubMed:15212762).
Figures for this product are not available in this catalogue.
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Dispatch Time
- About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.
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Product Inquiry
FNab05757 — NLRP1 antibody