Products
RPS3 antibody
Category:
- Catalogue No.:
- FNab07476
- Alias:
- Small ribosomal subunit protein uS3|40S ribosomal protein S3|RPS3 antibody
- Gene Name:
- RPS3
- UniProt ID:
- P23396
- Product Name
- RPS3 antibody
- Catalogue No.
- FNab07476
- Gene Name
- RPS3
- UniProt ID
- P23396
- Alias
- Small ribosomal subunit protein uS3|40S ribosomal protein S3|RPS3 antibody
- Isotype
- IgG
- Form
- liquid
- Purification
- Immunogen affinity purified
- Immunogen
- ribosomal protein S3
- Recommended dilution
- WB: 1:500-1:2000; IHC: 1:20-1:200
- Purity
- ≥95% as determined by SDS-PAGE
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Background
- Involved in translation as a component of the 40S small ribosomal subunit(PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA(PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA(PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine(8-oxoG), a common DNA lesion caused by reactive oxygen species(ROS)(PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA(PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1(PubMed:15518571). Enhances the uracil excision activity of UNG1(PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1(PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage(PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide(PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes(PubMed:18045535). Represses its own translation by binding to its cognate mRNA(PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination(PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization(PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8(PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5(PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation(PubMed:22510408).
Figures for this product are not available in this catalogue.
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Dispatch Time
- About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.
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FNab07476 — RPS3 antibody