Products
TNFSF11 antibody
Category:
- Catalogue No.:
- FNab09838
- Alias:
- Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF)|Osteoprotegerin ligand (OPGL)|Receptor activator of nuclear factor kappa-B ligand (RANKL)|TNF-related activation-induced cytokine (TRANCE)|Tumor necrosis factor ligand superfamily member 11 antibody, membrane form|Tumor necrosis factor ligand superfamily member 11 antibody, soluble form|TNFSF11|OPGL|RANKL|TRANCE antibody
- Gene Name:
- TNFSF11
- UniProt ID:
- O14788
- Product Name
- TNFSF11 antibody
- Catalogue No.
- FNab09838
- Gene Name
- TNFSF11
- UniProt ID
- O14788
- Alias
- Tumor necrosis factor ligand superfamily member 11|Osteoclast differentiation factor (ODF)|Osteoprotegerin ligand (OPGL)|Receptor activator of nuclear factor kappa-B ligand (RANKL)|TNF-related activation-induced cytokine (TRANCE)|Tumor necrosis factor ligand superfamily member 11 antibody, membrane form|Tumor necrosis factor ligand superfamily member 11 antibody, soluble form|TNFSF11|OPGL|RANKL|TRANCE antibody
- Isotype
- IgG1
- Clone ID
- 4F11
- Form
- liquid
- Purification
- Protein A+G purification
- Immunogen
- tumor necrosis factor (ligand) superfamily, member 11
- Recommended dilution
- WB: 1:1000-1:5000
- Purity
- ≥95% as determined by SDS-PAGE
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Background
- TNFSF11 also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. RANKL induces osteoclast formation through its receptor, RANK, which transduces signals by recruiting adaptor molecules, such as the TNF receptor-associated factor (TRAF) family of proteins. RANKL was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. RANKL was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Figures for this product are not available in this catalogue.
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
- Dispatch Time
- About 3 working days
Ordering & Delivery
How do I place an order?
Use the Inquiry button on this page or write to tekintolga89@gmail.com. Include the catalogue number and the quantity you need.
What is the dispatch time?
In-stock items are dispatched within 1-3 business days. Items that need to be produced take longer; we confirm the date when you order.
Do you ship outside Türkiye?
Shipping is arranged case by case. Contact us with the destination and we will quote carriage and lead time.
Storage & Handling
How should an unopened kit be stored?
At 2-8 °C unless the datasheet says otherwise. Do not freeze a kit that is not marked for freezing.
How long is an opened kit stable?
It depends on the component. The Kit Components table on this page lists the storage condition for each item after opening.
What should I do if the shipment arrives warm?
Photograph the package and contact us the same day. Do not use the kit until we have confirmed it is still within specification.
Assay Questions
Which sample types can I use?
The Sample Type row in the specifications above lists the validated matrices for this product. Other matrices need validation on your side.
My background is too high. What should I check?
The usual causes are insufficient washing, contaminated buffers, or too much detection antibody. Our Protocol pages cover the full troubleshooting sequence.
Can I run fewer wells than the kit provides?
Yes. Dismountable microplates let you use part of a plate and reseal the rest with the desiccant supplied.
Technical Support
Something did not work. What do you need from me?
Send the catalogue number, the lot, your protocol deviations and the raw OD values. That is usually enough to identify the cause.
Do you provide a certificate of analysis?
Yes, per lot. Ask for it with the catalogue number and lot number.
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FNab09838 — TNFSF11 antibody